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焦虑状态前额叶皮层动作电位因果网络连接模式的研究

保学辉 董浩然 刘迢迢 郑旭媛

保学辉, 董浩然, 刘迢迢, 郑旭媛. 焦虑状态前额叶皮层动作电位因果网络连接模式的研究[J]. 仁和测试, 2020, 37(3): 389-398. doi: 10.7507/1001-5515.201907011
引用本文: 保学辉, 董浩然, 刘迢迢, 郑旭媛. 焦虑状态前额叶皮层动作电位因果网络连接模式的研究[J]. 仁和测试, 2020, 37(3): 389-398. doi: 10.7507/1001-5515.201907011
Xuehui BAO, Haoran DONG, Tiaotiao LIU, Xuyuan ZHENG. Connectivity pattern of action potentials causal network in prefrontal cortex during anxiety[J]. Rhhz Test, 2020, 37(3): 389-398. doi: 10.7507/1001-5515.201907011
Citation: Xuehui BAO, Haoran DONG, Tiaotiao LIU, Xuyuan ZHENG. Connectivity pattern of action potentials causal network in prefrontal cortex during anxiety[J]. Rhhz Test, 2020, 37(3): 389-398. doi: 10.7507/1001-5515.201907011

焦虑状态前额叶皮层动作电位因果网络连接模式的研究

doi: 10.7507/1001-5515.201907011
基金项目: 国家自然科学基金(61976157)
详细信息
    通讯作者:

    郑旭媛,Email:zhengxuyuan@tmu.edu.cn

Connectivity pattern of action potentials causal network in prefrontal cortex during anxiety

Funds: The National Natural Science Foundation of China
More Information
  • 摘要: 焦虑症是常见的情绪障碍类疾病,严重影响着患者正常生活并危害其身心健康。前额叶皮层是焦虑的重要责任脑区。应用清醒动物在体多通道微电极阵列记录技术可以同时获取大鼠在高架十字迷宫(EPM)焦虑状态的动作电位和行为学数据。基于极大似然估计方法(MLE)构建动作电位因果网络,计算网络连接强度和全局效率,定量表征大鼠焦虑状态内侧前额叶皮层动作电位因果网络连接模式。研究发现大鼠在高架十字迷宫封闭臂的进入次数(44.13±6.99)和停留时间(439.76±50.43)s,均高于开放臂的进入次数(16.50±3.25,P<0.001)和停留时间[(160.23±48.22)s,P<0.001]。封闭臂中的动作电位因果网络连接强度(0.017 3±0.003 6)和全局效率(0.044 2±0.012 8),均高于开放臂的网络连接强度(0.010 4±0.003 2,P<0.01)和全局效率(0.034 8±0.011 4,P<0.001),从封闭臂走向开放臂过程中连接强度与全局效率减弱。结果表明内侧前额叶皮层动作电位因果网络变化与焦虑状态有关,该结果可为研究焦虑状态的前额叶皮层脑网络机制提供支持。
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出版历程
  • 收稿日期:  2019-07-05
  • 修回日期:  2019-12-21
  • 刊出日期:  2020-03-17

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